Newcastle United winger Christian Atsu has pulled out of the Ghana squad after sustaining an injury.
The star will not be available for the Uganda Cranes 2018 World Cup qualifier match at Namboole on Saturday.
He joins captain Asamoah Gyan, striker Thomas Agyepong, US-based duo Harrison Afful and Jonathan Mensah.
Ghana coach Appiah is however hoping the remaining team will not disappoint.
We tried to increase the number of players in camp should any one sustain any injury so that other players can fit in.
However, it looks like injury situation is increasing day in and day out and it is a little frustrating but we are trying to manage with what we have currently.
We were hoping to get the full house but unfortunately Thomas Agyepong, Harrison, Jonathan Mensah, Asamoah Gyan and Afriyie Aquah are all out.
We are still monitoring the other players before the game on Saturday and that is why it is a national team. You don’t always depend on few players.
We are hoping those in camp will give up their best to get victory for the nation
Ghana will leave Kenya – where they have been camping – on Thursday night aboard Kenya Airways for Kampala.